1 resultado para major histocompatibility antigen class 1
em Research Open Access Repository of the University of East London.
Filtro por publicador
- Aberdeen University (1)
- Academic Archive On-line (Stockholm University; Sweden) (1)
- Adam Mickiewicz University Repository (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (4)
- Aquatic Commons (7)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (5)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (1)
- Aston University Research Archive (32)
- Biblioteca de Teses e Dissertações da USP (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (13)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (14)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (5)
- Bioline International (2)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (62)
- Brock University, Canada (3)
- Bulgarian Digital Mathematics Library at IMI-BAS (1)
- CaltechTHESIS (3)
- CentAUR: Central Archive University of Reading - UK (22)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (21)
- Cochin University of Science & Technology (CUSAT), India (3)
- Coffee Science - Universidade Federal de Lavras (2)
- CORA - Cork Open Research Archive - University College Cork - Ireland (2)
- Dalarna University College Electronic Archive (2)
- Deakin Research Online - Australia (38)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (8)
- Digital Archives@Colby (2)
- Digital Commons - Michigan Tech (1)
- Digital Commons at Florida International University (2)
- DigitalCommons - The University of Maine Research (1)
- DigitalCommons@The Texas Medical Center (14)
- DigitalCommons@University of Nebraska - Lincoln (2)
- DRUM (Digital Repository at the University of Maryland) (1)
- Duke University (8)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (5)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (6)
- Helda - Digital Repository of University of Helsinki (7)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Indian Institute of Science - Bangalore - Índia (18)
- Institutional Repository of Leibniz University Hannover (1)
- Instituto Politécnico do Porto, Portugal (2)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (1)
- National Center for Biotechnology Information - NCBI (199)
- Publishing Network for Geoscientific & Environmental Data (13)
- QSpace: Queen's University - Canada (4)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (49)
- Queensland University of Technology - ePrints Archive (121)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- Repositório Científico da Universidade de Évora - Portugal (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (1)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (2)
- Repositório Institucional da Universidade de Brasília (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (77)
- Research Open Access Repository of the University of East London. (1)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (1)
- SAPIENTIA - Universidade do Algarve - Portugal (1)
- Savoirs UdeS : plateforme de diffusion de la production intellectuelle de l’Université de Sherbrooke - Canada (1)
- School of Medicine, Washington University, United States (1)
- Universidad de Alicante (2)
- Universidad del Rosario, Colombia (6)
- Universidad Politécnica de Madrid (2)
- Universidade Complutense de Madrid (3)
- Universidade de Lisboa - Repositório Aberto (3)
- Universidade Federal do Pará (6)
- Universidade Federal do Rio Grande do Norte (UFRN) (8)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (16)
- Université de Montréal (3)
- Université de Montréal, Canada (28)
- University of Michigan (9)
- University of Queensland eSpace - Australia (24)
- University of Washington (2)
- Worcester Research and Publications - Worcester Research and Publications - UK (1)
Resumo:
Direct allorecognition is the process by which donor-derived major histocompatibility complex (MHC)-peptide complexes, typically presented by donor-derived ‘passenger’ dendritic cells, are recognised directly by recipient T cells. In this review, we discuss the two principle theories which have been proposed to explain why individuals possess a high-precursor frequency of T cells with direct allospecificity and how self-restricted T cells recognise allogeneic MHCpeptide complexes. These theories, both of which are supported by functional and structural data, suggest that T cells recognising allogeneic MHC-peptide complexes focus either on the allopeptides bound to the allo-MHC molecules or the allo-MHC molecules themselves. We discuss how direct alloimmune responses may be sustained long term, the consequences of this for graft outcome and highlight novel strategies which are currently being investigated as a potential means of reducing rejection mediated through this pathway.